Furosemide Impurity 18 CAS 2708280-93-5 (free base)
| CAS No. | 2708280-93-5 (free base) |
| Molecular Formula | C12H9ClN3O6S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Furosemide Impurity 18 (CAS 2708280-93-5 (free base)), a pharmacopoeial impurity reference standard (molecular formula C12H9ClN3O6SNa, MW 381.72 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a salt form, a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Furosemide Impurity 18 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 381.72 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H9ClN3O6S Na |
| Molecular Weight | 381.72 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 64 (CAS 116436-17-0)
- Furosemide-d5 (CAS 1189482-35-6)
- Furosemide Impurity 14 (CAS 133989-65-8)
- Furosemide Impurity 48 Sodium Salt (CAS 133989-65-8（free base）)
- Furosemide Impurity 41 (CAS 137-65-5)
- Furosemide Impurity 33 (CAS 1803102-41-1)
- Furosemide Impurity 32 (CAS 18240-50-1)
- Furosemide Impurity 57 (CAS 19377-82-3)
Recommended Standards
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- N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-2-bromo-N-methyl-D-tryptophan (CAS 131791-79-2)
- (2R,3S,4S,5R,6S)-2-((Benzoyloxy)methyl)-6-(phenylthio)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate (CAS 65615-60-3)
- benzyl 2-bromoisonicotinate (CAS 1820685-09-3)
- 1-(2-Amino-1-(4-chlorophenyl)ethyl)pyrrolidine-3-carboxylic acid (CAS 886364-00-7)
- Methyl 2-(pyrrolidin-3-yl)thiazole-5-carboxylate hydrochloride (CAS 2137717-09-8)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
Why CATO?
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